How does chromatin impact post-transcriptional RNA fates?

Chromatin is known to impact expression of the underlying genomic sequence. Regulation of transcription and the control of the post-transcriptional fate of RNAs – such as RNA processing, RNA editing, nuclear export, translation and RNA degradation – are often viewed as two independent processes. However, accumulating evidence suggests that the two steps are tightly linked and that chromatin is also involved in post-transcriptional gene regulation: some proteins that define the future fate of an RNA bind co-transcriptionally in a manner that depends on specific transcription factors and chromatin structure of the locus. We use a systems biology approach to investigate how chromatin influences the fate of emerging transcripts.